Accession Number : ADA185962

Title :   Anti-Cyanide Drugs.

Descriptive Note : Annual summary rept. 1 Apr 85-31 Mar 86,

Corporate Author : HOWARD UNIV WASHINGTON DC DEPT OF CHEMISTRY

Personal Author(s) : Hambright, Peter

PDF Url : ADA185962

Report Date : 01 May 1986

Pagination or Media Count : 21

Abstract : Both metal ion complexes and unsaturated organic compounds are being explored as potential in vivo anti-cyanide drugs. Certain water soluble metalloporphyrins containing cobalt (III), silver (II), chromium (II), rhodium (III), palladium (II), or iron (III), and cobalt (II), and (III) sulfonated phthalocyanines have been shown to rapidly complex cyanide at physiological pH. Detailed kinetic work indicates than both cyanide and HCN are reactants. A number of five, six and seven membered ring systems with activated double bonds known as alkylidenes have been shown to complex cyanide. Kinetic work indicates a rate law first order in each reactant, then a following cyanide independent rearrangement, forming a low molecular weight covalently bound cyanide species, with the loss of water and carbon dioxide. Twenty such drugs have been synthesized. Keywords: Antidotes; Therapy.

Descriptors :   *ANTIDOTES, *CYANIDES, ACTIVATION, CARBON DIOXIDE, CHROMIUM, COBALT, DRUGS, IRON, KINETICS, LIGHTWEIGHT, LOSSES, METAL COMPLEXES, MOLECULAR WEIGHT, ORGANOMETALLIC COMPOUNDS, PALLADIUM, PH FACTOR, PHTHALOCYANINES, PHYSIOLOGY, PORPHYRINS, RATES, RHODIUM, RINGS, SILVER, SOLUBILITY, SULFONATES, THERAPY, WATER

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE