Accession Number : ADA186194

Title :   Pharmacological Resetting of the Circadian Sleep-Wake Cycle.

Descriptive Note : Annual technical rept. 1 May 86-30 Apr 87,

Corporate Author : HARVARD MEDICAL SCHOOL BOSTON MA DEPT OF PHYSIOLOGY AND BIOPHYSICS

Personal Author(s) : Moore-Ede, Martin C

PDF Url : ADA186194

Report Date : 30 May 1987

Pagination or Media Count : 6

Abstract : This research project is investigating strategies to pharmacologically manipulate the circadian sleep-wake cycle in order to control the timing of alert function and of sleep in altered work schedule environments. In the past year we have investigated the benzodiazepines,diazepam (in hamsters) and triazolam (in squirrel monkeys), and have derived a phase response curve for each. In optically-enucleated hamsters, however, consistent phase shifts were not obtained suggesting that diazepam acts on light information-conveying pathways. Biochemical receptor binding studies are defining the benzodiazepine receptor density in various brain regions. In addition, the characterization of the circadian and homeostatic components of sleep in the squirrel monkey during sleep deprivation studies is being conducted in preparation for pharmacological manipulation with benzodiazepines. Keywords: Mathematical modeling; Jet-lag.

Descriptors :   *CIRCADIAN RHYTHMS, *HYPNOTICS AND SEDATIVES, BRAIN, CONSISTENCY, CONTROL, DIAZEPAM, GRAPHS, HAMSTERS, HOMEOSTASIS, MATHEMATICAL MODELS, PHASE SHIFT, RESPONSE, SCHEDULING, SLEEP, SLEEP DEPRIVATION, SQUIRREL MONKEYS, BIOCHEMISTRY, BRAIN, CIRCADIAN RHYTHMS, CONSISTENCY, CONTROL, DIAZEPAM, GRAPHS, HAMSTERS, HOMEOSTASIS, MATHEMATICAL MODELS, PHASE SHIFT, RESPONSE, SCHEDULING, SENSE ORGANS, SLEEP, SLEEP DEPRIVATION, SQUIRREL MONKEYS, CONSCIOUSNESS, JET LAG, HOMEOSTASIS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE