Accession Number : ADA186245

Title :   The Use of ATP-MgCl2 in the Treatment of Injury and Shock.

Descriptive Note : Final rept. 1 Oct 75-31 Jul 81,

Corporate Author : YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE

Personal Author(s) : Baue, Arthur E ; Chaudry, Irshad H

PDF Url : ADA186245

Report Date : 11 Mar 1986

Pagination or Media Count : 45

Abstract : Studies were conducted to compare the effects of positive end-expiratory pressure (PEEP) and zero end-expiratory pressure (ZEEP) in experimentally induced Pseudomonas pneumonia. Our results indicated a conspicuous advantage of PEEP over ZEEP in experimentally-induced Pseudomonas pneumonia, not only in terms of improved cardiopulmonary function but also in terms of survival. The mechanisms by which PEEP improves the survival of dogs with Pseudomonas pneumonia may be due to an improvement in pulmonary macrophage function. In studies of circulatory failure, the results indicated that the extent pf which ATP levels decrease during shock may be related to the metabolic activity of the organ or tissue. Moreover, membrane-bound sodium-potassium transport mechanism and not membrane permeability is directly affected in shock. In addition, our results indicated that tissue ATP levels are a more sensitive indicator of hypoxia than NAD levels. Keywords: Hemorrhagic shock; Hepatic ischemia; Renal failure; Sepsis.

Descriptors :   *HEMORRHAGIC SHOCK, *CHEMOTHERAPY, *DISEASES, *ADENOSINE PHOSPHATES, *MAGNESIUM COMPOUNDS, *CHLORIDES, DOGS, HYPOXIA, INFECTIOUS DISEASES, METABOLIC DISEASES, ORGANS(ANATOMY), PERMEABILITY, PHAGOCYTES, PNEUMONIA, PSEUDOMONAS, PULMONARY FUNCTION, RETICULOENDOTHELIAL SYSTEM, SURVIVAL(GENERAL), WOUNDS AND INJURIES, MEMBRANES(BIOLOGY), KIDNEY DISEASES, LIVER DISEASES, ISCHEMIA, SPLEEN, CARDIOVASCULAR DISEASES, RESPIRATION, PRESSURE, RATS, SWINE

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE