Accession Number : ADA186459

Title :   Pyridostigmine, 2-PAM and Atropine: Effects on the Ability to Work in the Heat,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Francesconi, R P ; Bosselaers, M ; Matthew, C B ; Leva, N ; Hubbard, R W

PDF Url : ADA186459

Report Date : Apr 1987

Pagination or Media Count : 7

Abstract : Adult, male rats had access to either tap water or tap water containing 300 mg/L of pyridostigmine bromide (PYR) for 1 week prior to experimentation; this was followed by exercise at 30 C to hyperthermic exhaustion. Thirty min prior to the exercise, pyridostigmine (PYR) - and water-drinking groups were treated with an additional intraperitoneally administered regimen: saline, atropine sulfate, pyridine-2-aldoxime methiodide, or atropine plus pyridine-2-aldoxime methiodide. PYR rats drank significantly more than their tap water drinking counterparts although mean daily food consumption was unaffected by PYR. Mean endurances ranged from 50.4 min (PYR-ATR-2-PAM) to 76.3 min (PYR). The 4 groups receiving 2-PAM manifested a mean endurance of 53.9 min while the 4 groups not receiving 2-PAM had a mean endurance of 66.2 min. PYR-pretreatment elicited a 25% inhibition of plasma cholinesterase while in the two groups consuming PYR and treated with 2-PAM, inhibition was approximately 10%. Osmolality, lactic acid dehydrogenase, creatinine, urea nitrogen, and lactate were elevated by the heat-exercise. There were indications (endurance capacity and CPK efflux) that 2-PAM may have subsequent adverse effects on the ability to work in the heat. While indices of heat/exercise injury were ordinarily increased by exercise in the heat, elevations were generally unaffected by pharmacological intervention.

Descriptors :   *EXERCISE(PHYSIOLOGY), *HYPERTHERMIA, *ANTIDOTES, *ENDURANCE(PHYSIOLOGY), ADVERSE CONDITIONS, ATROPINE, BROMIDES, CARBAMATES, CHOLINESTERASE, CREATININE, DAILY OCCURRENCE, FATIGUE(PHYSIOLOGY), FOOD CONSUMPTION, HEAT, HYDROXYL RADICALS, INHIBITION, INTERVENTION, LACTATES, LACTIC ACID, LACTIC DEHYDROGENASE, MALES, MEAN, METHYL RADICALS, NITROGEN, OSMOSIS, PHARMACOLOGY, PYRIDINES, RATS, SULFATES, UREA, WATER, WOUNDS AND INJURIES, CHOLINESTERASE INHIBITORS

Subject Categories : Pharmacology
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE