Accession Number : ADA186495

Title :   Immunomodulation by Drugs Which Inhibit Suppressor Cell Function in Traumatized Mice.

Descriptive Note : Annual rept. 15 Aug 86-15 Aug 87,

Corporate Author : CALIFORNIA UNIV MEDICAL CENTER SAN DIEGO

Personal Author(s) : Hasbrough, John F

PDF Url : ADA186495

Report Date : 21 Sep 1987

Pagination or Media Count : 10

Abstract : The purpose of this project is to determine if the immunosuppression which occurs after severe injury can be reversed or prevented by pharmacologic agents. The first step has been to set up defined measures of immunity which reflect postinjury immunosuppression in the mouse. These assays have now been set up; they include T cell subset analysis (blood, lymph node, spleen), T cell mitogenic response with assay for surface antigen expression, neutrophil (PMN) phagocytosis, PMN chemiluminescence, and serum opsonic activity. We are now ready to begin to study the effect of various drugs on these immune functions, which are all inhibited in the injury model. The drugs to be studied in the 3rd year include prostaglandin blockers, histamine-2 antagonists, and cyclophosphamide, an alkylating agent which in low-dose has been shown to inhibit suppressor cell proliferation. Keywords: Trauma, Lymphocytes; Neutrophils; Immunomodulation, Suppressor cells.

Descriptors :   *DRUGS, *IMMUNOSUPPRESSION, *IMMUNOCHEMISTRY, ALKYLATION, ANTIGENS, BLOOD, CELLS(BIOLOGY), CHEMILUMINESCENCE, CYCLOPHOSPHAMIDE, IMMUNITY, LYMPH, LYMPHOCYTES, MICE, MODELS, NODES, POLYMORPHONUCLEAR NEUTROPHILS, RETICULOENDOTHELIAL SYSTEM, SPLEEN, SURFACES, TRAUMA, WOUNDS AND INJURIES, LABORATORY ANIMALS, PROSTAGLANDIN, THERAPY, PHARMACOLOGICAL ANTAGONISTS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE