Accession Number : ADA186577

Title :   Role of Water in Proton-Hydroxide Conductance Across Model and Biological Membranes.

Descriptive Note : Annual rept.,

Corporate Author : CALIFORNIA UNIV DAVIS DEPT OF ZOOLOGY

Personal Author(s) : Deamer, David W

PDF Url : ADA186577

Report Date : 10 Nov 1987

Pagination or Media Count : 8

Abstract : The goal of this research is to understand the barrier properties of lipid bilayers, and particularly the role of transient defects in providing pathways for ion flux. Our approach is to compare proton and potassium flux, using membrane perturbants to probe the barrier. We have found that perturbants such as n-alkanols and diols cause increments in cation flux, which can be used to predict anesthetic effects. The increments are caused by increased numbers of hydrated defects, and we have used the gramicidin channel to test properties of transmembrane strands of hydrogen bonded water which would model such defects. Keywords: Ion transport; Membranes (biology).

Descriptors :   *ION EXCHANGE, *MEMBRANES(BIOLOGY), *MOLECULAR BIOLOGY, ANESTHETICS, BARRIERS, CATIONS, FLUX(RATE), HYDRATES, ION DENSITY, LAYERS, LIPIDS, POTASSIUM, TRANSIENTS, WATER, HYDROGEN BONDS, PERMEABILITY, PROTONS

Subject Categories : Genetic Engineering and Molecular Biology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE