Accession Number : ADA186580

Title :   Annual Report: September 1987.

Descriptive Note : Rept. for Oct 86-Oct 87,

Corporate Author : MARYLAND UNIV COLLEGE PARK DEPT OF ZOOLOGY

Personal Author(s) : Colombini, Marco

PDF Url : ADA186580

Report Date : 28 Sep 1987

Pagination or Media Count : 3

Abstract : The molecular mechanism underlying the voltage dependence of the mitochondrial channel, VDAC, is the general aim of the research. The approaches used to move toward that goal were: succinic anhydride modification, regulation by aqueous aluminum species and polyanions, and kinetic analysis. The results indicate that the voltage sensor and selectivity filter are distinct groups of charges, probably amino groups. The sensor is probably not located in the channel proper but on one or the other surfaces of the membrane where it can interact with high molecular weight polyanions. The kinetic studies are in their early stages but indicate the presence of unusual physical phenomena. Keywords: Membranes(Biology); Membrane channel; Voltage dependence; Aluminum; Polyanion protein modification.

Descriptors :   *MITOCHONDRIA, *MOLECULAR BIOLOGY, *PROTEINS, ALUMINUM, AMINES, ANHYDRIDES, CHANNELS, DETECTORS, KINETICS, LIQUIDS, MEMBRANES, MODIFICATION, MOLECULES, PHYSICAL PROPERTIES, SUCCINIC ACID, SURFACES, AMINO ACIDS, MEMBRANES(BIOLOGY), ELECTROPHYSIOLOGY

Subject Categories : Genetic Engineering and Molecular Biology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE