Accession Number : ADA186580
Title : Annual Report: September 1987.
Descriptive Note : Rept. for Oct 86-Oct 87,
Corporate Author : MARYLAND UNIV COLLEGE PARK DEPT OF ZOOLOGY
Personal Author(s) : Colombini, Marco
PDF Url : ADA186580
Report Date : 28 Sep 1987
Pagination or Media Count : 3
Abstract : The molecular mechanism underlying the voltage dependence of the mitochondrial channel, VDAC, is the general aim of the research. The approaches used to move toward that goal were: succinic anhydride modification, regulation by aqueous aluminum species and polyanions, and kinetic analysis. The results indicate that the voltage sensor and selectivity filter are distinct groups of charges, probably amino groups. The sensor is probably not located in the channel proper but on one or the other surfaces of the membrane where it can interact with high molecular weight polyanions. The kinetic studies are in their early stages but indicate the presence of unusual physical phenomena. Keywords: Membranes(Biology); Membrane channel; Voltage dependence; Aluminum; Polyanion protein modification.
Descriptors : *MITOCHONDRIA, *MOLECULAR BIOLOGY, *PROTEINS, ALUMINUM, AMINES, ANHYDRIDES, CHANNELS, DETECTORS, KINETICS, LIQUIDS, MEMBRANES, MODIFICATION, MOLECULES, PHYSICAL PROPERTIES, SUCCINIC ACID, SURFACES, AMINO ACIDS, MEMBRANES(BIOLOGY), ELECTROPHYSIOLOGY
Subject Categories : Genetic Engineering and Molecular Biology
Distribution Statement : APPROVED FOR PUBLIC RELEASE