Accession Number : ADA186594

Title :   Effects of Organophosphate Esters on Neuropeptide Systems.

Descriptive Note : Annual rept. 1983-1984,

Corporate Author : STATE UNIV OF NEW YORK AT ALBANY RESEARCH FOUNDATION

Personal Author(s) : McKelvy, Jeffrey F

PDF Url : ADA186594

Report Date : 01 Mar 1986

Pagination or Media Count : 12

Abstract : Organophosphate esters were studied in terms of their ability to affect neuropeptides in the rat central nervous system. The in vivo biosynthesis of enkephalin peptides in the basal ganglia and of vasopressin and oxytocin in the hypothalamus were studied and the effect of subcutaneous administration of diisopropylfluorophosphate (DFP) in the biosynthesis of these neuropeptides was assessed. It was found that DFP inhibited the biosynthesis of vasopressin and oxytocin. These results suggest that organophosphates exert their effects not only on cholinergic systems but also on neuropeptide systems important in endocrine and cardiovascular function.

Descriptors :   *BIOSYNTHESIS, *ORGANOPHOSPHATES, *PEPTIDES, *ESTERS, *TOXICITY, GANGLIA, CARDIOVASCULAR SYSTEM, IN VIVO ANALYSIS, CHOLINERGIC NERVES, HYPOTHALAMUS, NERVES, ORGANOPHOSPHATES, PITUITARY HORMONES, CENTRAL NERVOUS SYSTEM, RATS, BIOCHEMISTRY, PITUITARY HORMONES

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE