Accession Number : ADA186687

Title :   Molecular Dynamics of Calmodulin.

Descriptive Note : Annual rept. 1 Aug 76-30 Jul 87,

Corporate Author : MAYO CLINIC ROCHESTER MN

Personal Author(s) : Prendergast, Franklyn G

PDF Url : ADA186687

Report Date : 15 Aug 1987

Pagination or Media Count : 13

Abstract : Our longterm objective is an understanding of the molecular basis of calmodulin activation of target enzymes. We have chosen the interaction of calmodulin with peptides as an initial paradigm to simplify the study of the molecular details of the peptide-protein interaction. Our initial focus has been the development of methodology for the experimental study of the molecular dynamics of calmodulin binding-peptides, and of calmodulin-peptides complexes, in particular an evaluation of the conjoint use of fluorescence and NMR spectroscopy in such studies.

Descriptors :   *ACTIVATION, *ENZYMES, *PEPTIDES, DYNAMICS, FLUORESCENCE, METHODOLOGY, MOLECULAR PROPERTIES, SPECTROSCOPY, TARGETS, ACTIVATION

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE