Accession Number : ADA186693

Title :   Properties of Stabilized Sub-Micron Phospholipid Vesicles.

Descriptive Note : Final rept. 15 Apr 86-14 Apr 87,

Corporate Author : CALIFORNIA INST OF TECH PASADENA

Personal Author(s) : Baldeschwieler, John D

PDF Url : ADA186693

Report Date : 29 May 1987

Pagination or Media Count : 4

Abstract : The principal focus of research activity has been the characterization of phospholipid vesicles formed with polymerizable disulfide phosphatidylcholines. Structures with the polymerizable groups in both the alpha and terminal positions of the side chain fatty acids have been synthesized and the resulting polymerized structures characterized. We have discovered that it is possible to produce very small and highly stable polymerized micellular structures using short chain phosphatidylcholines. Extremely stable phospholipid vesicles can be produced using long chain fatty acids polymerized in the alpha position. We have also studied novel synthetic glycolipids in incorporated into phospholipid vesicle structures. These synthetic glycolipids modify the lipid phase behavior substantially and produce vesicles which are stable to lyophylization. The details of these studies have been prepared for publication, and are given in the attached preprint entitled Modification of Lipid Phase Behavior With Membrane Bound Cryoprotectants by Raymond P. Goodrich, Tracy M. Handel, and John D. Baldeschwieler.

Descriptors :   *PHOSPHOLIPIDS, POSITION(LOCATION), FATTY ACIDS, POLYMERIZATION, CHAINS, LIPIDS, PHASE STUDIES, MEMBRANES, GLYCOLIPIDS, POLYMERS, MOLECULAR PROPERTIES, MOLECULAR STRUCTURE

Subject Categories : Genetic Engineering and Molecular Biology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE