Accession Number : ADA186834

Title :   Long Term Synaptic Plasticity and Learning in Neuronal Networks.

Descriptive Note : Annual technical rept. 15 Aug 86-14 Aug 87,

Corporate Author : CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA

Personal Author(s) : Brown, Thomas H

PDF Url : ADA186834

Report Date : 14 Sep 1987

Pagination or Media Count : 7

Abstract : The working hypothesis has been that longterm synaptic potentiation may mediate certain of the mnemonic functions of the hippocampal circuitry. The discovery of an underlying Hebbian conjunctive mechanism has boosted confidence in this hypothesis. One major effort of the past year was to summarize and integrate this AFOSR supported discovery into a more general theoretical and experimental framework. In regard to the 4 specific aims, development of the fluctuation algorithm has been completed, and it was applied to synaptic fluctuations obtained using the loose patch clamp method (aim 2). THe algorithm is currently running on a mainframe at UCLA. It is now being implemented on a small workstation (Macintosh II). As soon as it is working on the Mac II, the quantal analysis in hippocampus will begin (aim 1). The culture method is underway (aim 3) and a first-generation video microscopic technique was developed for visualizing neurons and their synapses to see if the latter move during activity (aim 4).

Descriptors :   *NERVE CELLS, *SYNAPSE, *LEARNING, *NEURAL NETS, ALGORITHMS, HIPPOCAMPUS, HYPOTHESES, LEARNING, MICROSCOPY, MNEMONICS, NETWORKS, PLASTIC PROPERTIES, PROTOTYPES, VARIATIONS, VIDEO SIGNALS, WORK, NEUROPHYSIOLOGY, NERVE TRANSMISSION, CULTURES(BIOLOGY), BIOPHYSICS, MOLECULAR BIOLOGY

Subject Categories : Biochemistry
      Anatomy and Physiology
      Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE