Accession Number : ADA186840

Title :   Investigation of Non-Linear Dielectric Behavior of Sickle Cell Hemoglobin.

Descriptive Note : Final rept. Jun 85-Oct 87,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA DEPT OF CHEMICAL AND BIOCHEMICAL ENGINEERING

Personal Author(s) : Takashima, Shiro

PDF Url : ADA186840

Report Date : 11 Nov 1987

Pagination or Media Count : 21

Abstract : Linear and non linear dielectric properties of sickle cell anemia hemoglobin were investigated. Under normal conditions where sickle cell hemoglobin is distributed randomly in solution, their dielectric behavior is only slightly different from that of normal hemoglobin. When they form liquid crystalline gel, major portion of the hemoglobin S molecules become interlocked in gel lattice and dielectric constant decrease. However, the dielectric properties of free hemoglobin S which do not participate in gel formation, remain by and large unaltered. The presence of large gels imposes some constraints on the rotation of free hemoglobin. Hb S gels seem to be unstable mechanically and electrically. Relatively small mechanical shear is sufficient to cause degradation of the gel. Likewise, moderate electrical fields (10-20 V/cm) seem to cause underfined perturbation of gel lattices.

Descriptors :   *DIELECTRIC PROPERTIES, *HEMOGLOBIN, *SICKLE CELL ANEMIA, CONSTANTS, DEGRADATION, ELECTRIC FIELDS, GELS, LIQUID CRYSTALS, MECHANICAL PROPERTIES, MOLECULES, NONLINEAR SYSTEMS, ROTATION, SHEAR PROPERTIES, SICKLE CELLS, BLOOD CHEMISTRY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE