Accession Number : ADA187145

Title :   Phosphoprotein Regulation of Synaptic Reactivity: Enhancement of a Molecular Gating Mechanism.

Descriptive Note : Annual progress rept.,

Corporate Author : NORTHWESTERN UNIV EVANSTON IL COLL OF ARTS AND SCIENCES

Personal Author(s) : Routtenberg, Aryeh

PDF Url : ADA187145

Report Date : 15 Aug 1987

Pagination or Media Count : 10

Abstract : This research is focussed on the role of molecular switches in brain which regulate synaptic reactivity. We have identified a 47,000 mol wt phosphoprotein and its kinase (c) which play a pivotal role in this regulation. We have enhanced communication among nerve cells studied electrophysiologically by activation of this kinase. In the proposed research we specifically manipulate this brain phosphoprotein with novel kinase activating agents. In a new initiative, both the kinase and the F1 substrate will be studied with the goal of enhancing synaptic reactivity by regulating the activity of proteins that play a pivotal role in this process. Keywords: Nerve transmission; Synapse; Plasticity; Reactivity; Phosphorylation; Protein kinase C; Protein F1; Fatty acids.

Descriptors :   *NERVE TRANSMISSION, *SYNAPSE, *PHOSPHOPROTEINS, *ELECTROPHYSIOLOGY, ACTIVATION, BRAIN, FATTY ACIDS, MOLECULES, NERVE CELLS, PHOSPHORYLATION, PROTEINS, REACTIVITIES, SWITCHES, NEUROCHEMISTRY, REACTION KINETICS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE