Accession Number : ADA187273

Title :   Chronic Mammalian Toxicological Effects of LAP Wastewater.

Descriptive Note : Final rept. Sep 79-Jul 82,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Brown, Janice M ; Spanggord, Ronald J ; Jorgenson, Ted A

PDF Url : ADA187273

Report Date : Jun 1983

Pagination or Media Count : 253

Abstract : The objective of these studies was to provide a comprehensive definition of the long-term toxicological effects of LAP wastewater (TNT/RDX in a ratio of 1.6 to 1) on Fischer-344 rats with respect to possible lesions at the biochemical and cellular levels. Males receiving 200 mg/kg/day of LAP exhibited convulsions and death, the high-dose level was reduced to 100 mg/kg/day for both sexes after 12 weeks on test. Males at the mid-dose level showed an increase in mortality compared with controls at 104 weeks (study termination); these rats also exhibited convulsions and aggressive behavior. Low-dose males and females at both the low- and mid-dose levels showed little response with regard to behavioral or clinical abnormalities, food consumption, and mortality; however, body weights in these groups were significantly decreased throughout the study. Effects on both the myelocytic and erythrocytic series were seen in both sexes at the mid-dose level. A dose response was seen in glucose, uric acid, potassium, triglycerides, LDH, total iron, A/G ratio, sodium, CO2, and biluribin. Only LDH was significantly decreased in males at both levels. The principle LAP-induced lesions observed as histopathological examination were degenerative changes in the eye and urinary system and decreased cellularity of the lymphoid tissues.

Descriptors :   *TOXICITY, *RDX, *TNT, *WASTE WATER, BEHAVIOR, BIOCHEMISTRY, MAMMALS, TOXICOLOGY, DEATH, EYE, FOOD CONSUMPTION, ABNORMALITIES, CLINICAL MEDICINE, BODY WEIGHT, CONVULSIVE DISORDERS, DOSAGE, RESPONSE(BIOLOGY), FEMALES, GLUCOSE, CELLS(BIOLOGY), HISTOPATHOLOGY, PHYSIOLOGICAL EFFECTS, HIGH RATE, IRON, LOW LEVEL, MALES, RATIOS, SODIUM, GLYCERIDES, URINARY SYSTEM, LESIONS, LONG RANGE(TIME), LYMPHATIC SYSTEM, TISSUES(BIOLOGY), POTASSIUM, RATS, URIC ACID

Subject Categories : Water Pollution and Control
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE