Accession Number : ADA187395

Title :   Regulation of the Immune System by Hypothalamic Releasing Hormones.

Descriptive Note : Annual rept. Jul 86-Sep 87,

Corporate Author : TEXAS UNIV MEDICAL BRANCH AT GALVESTON

Personal Author(s) : Smith, Eric M

PDF Url : ADA187395

Report Date : 01 Nov 1987

Pagination or Media Count : 23

Abstract : It has been known for many years that stressful situations can be a contributing factor in the development of a variety of bacterial, viral and neoplastic diseases. Specifically, decreased immuno-competence seems to account for the increased susceptibility of stressed hosts for these disease states. We have suggested that one mechanism by which this can occur is through the action of neuroendocrine hormones. It appears that the immune and neuroendocrine systems communicate in a bidirectional regulatory circuit by virtue of common signal molecules and receptors. In this report we discuss our findings on the amino acid sequence and post translational processing of lymphocyte derived corticotropin (ACTH). Also, presented are results that hte hypothalamic releasing hormones for luteinizing hormone (LH) and thyrotropin (TSH) induce lymphocytes to synthesize immunoreactive LH and TSH, respectively. Finally, we discuss our data that the ACTH recepto on lymphocytes acts through adenylate cyclase like the prototype on adrenal tissue. Keywords: Hypothalamic releasing hormones, Stress, Immune system, ACTH, Endorphins, Corticosteroids, Monokines, Neuroimmunomodulation, Stress(Physiology).

Descriptors :   *HORMONES, *HYPOTHALAMUS, *NEUROCHEMISTRY, ADENYL CYCLASE, ADRENOCORTICOTROPIC HORMONE, AMINO ACIDS, CORTICOSTEROID AGENTS, DISEASES, ENDOCRINE GLANDS, IMMUNITY, LYMPHOCYTES, MOLECULES, NEOPLASMS, NEUROLOGY, PITUITARY HORMONES, RELEASE, SEQUENCES, SIGNALS, SYNTHESIS, THYROTROPIN, IMMUNOSUPPRESSION, STRESS(PSYCHOLOGY), EMOTIONS, PATHOPHYSIOLOGY

Subject Categories : Medicine and Medical Research
      Biochemistry
      Anatomy and Physiology
      Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE