Accession Number : ADA187403

Title :   Drug Evaluation in the Plasmodium falciparum-Aotus Model.

Descriptive Note : Annual rept. 1 Aug 84-31 Jul 85,

Corporate Author : GORGAS MEMORIAL LAB APO MIAMI 34002

Personal Author(s) : Rossan, Richard N

PDF Url : ADA187403

Report Date : 30 Sep 1985

Pagination or Media Count : 48

Abstract : The purpose of these studies was to evaluate experimental antimalarial drugs in a non-human primate model, viz. blood-induced infections of Plasmodium falciparum or P. vivax in the owl monkey, Aotus trivirgatus. Two strains of falciparum malaria, Uganda Palo Alto (sensitive to chloroquine and quinine, resistant to pyrimethamine) and Vietnam Smith (resistant of chloroquine, quinine and pyrimethamine), were used in these experiments. The strain of P. vivax was the New Guinea Chesson strain (sensitive to chloroquine, quinine and pyrimethamine). Results of the assessment of WR 245082, and acridineimine, indicated that its curative activity against the chloroquine-sensitive and the chloroquine-resistant strain was essentially identical. Three 8-aminoquinolines were evaluated for their activity against blood-induced infections of P. vivax. WR 249420, WR 249252 and WR 249700 were curative. An acridinol, WR 250547, cured blood-induced infections of P. vivax. WR 247705, a quinoline, was assessed for its activity against infections of the Uganda Palo Alto strain of P. falciparum. WR 251853, 2-fluoro-L-Histidine suppressed and parasitemia of the Uganda Palo Alto strain. WR 079520, desferrioxamine, an iron-specific chelating agent, was administered to Aotus infected with the Uganda Palo Alto strain of P. falciparum. The infection was not cured. The in vitro activity of deferrioxamine was not substantiated in vivo.

Descriptors :   *ANTIMALARIALS, DRUGS, IN VIVO ANALYSIS, INFECTIOUS DISEASES, QUINOLINES, TEST AND EVALUATION, STRAINS(BIOLOGY), PLASMODIUM FALCIPARUM, CHLOROQUINE, PYRIMETHAMINE, QUININE, PLASMODIUM VIVAX, OWL MONKEYS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE