Accession Number : ADA187478
Title : Inclusion Complexes of Diisopropyl Fluorophosphate with Cyclodextrins.
Descriptive Note : Rept. for Oct 86-Sep 87,
Corporate Author : NAVAL WEAPONS CENTER CHINA LAKE CA
Personal Author(s) : Hall, K S ; Nissan, R A ; Quintana, R L ; Hollins, R A
PDF Url : ADA187478
Report Date : Sep 1987
Pagination or Media Count : 20
Abstract : The hydrolysis of diisopropylfluorophosphate (DFP) and other phosphorus esters has been of great interest (1). The discovery of the enzyme DFPase shows great promise for the hydrolysis of DFP (2), but a major problem with enzymes is their poor stability and limited availability. Cyclodextrins are cyclic oligomers of glucose. The most common CDs are the hexamer, heptamer, and the octamer which have a molecular weight around 1000. Cyclodextrins have a conical doughnut shape with hydroxyl groups on the outer surface while the cavity is hydrophobic, similar to what would be expected for a miniature enzyme. The solubility of CD in water is good, making the inclusion of various apolar molecules possible (3). In solution a 1:1 molar ratio guest-host complex is usually formed. This interaction can enable enhanced reaction rates when CD or a functionalized CD is a reactant. Functional groups can be attached directly to the CD molecule making it catalytically active; first an inclusion complex must be formed with guest molecule.
Descriptors : *DEXTRINS, *FLUORINE COMPOUNDS, *PHOSPHATES, AVAILABILITY, ENZYMES, ESTERS, EXTERNAL, GLUCOSE, HYDROLYSIS, HYDROXYL RADICALS, MOLECULAR WEIGHT, MOLECULES, PHOSPHORUS, POLYMERS, SURFACES, WATER, MOLECULE MOLECULE INTERACTIONS, CATALYSTS, CHEMICAL BONDS, REACTION KINETICS
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE