Accession Number : ADA187555

Title :   Use of Moderately Hypertonic Sodium Chloride in the Resuscitation of Patients from Injury.

Descriptive Note : Annual rept. 1 Jul 85-30 Jun 86,

Corporate Author : CALIFORNIA UNIV DAVIS DEPT OF SURGERY

Personal Author(s) : Holcroft, James W ; Vassar, Mary J

PDF Url : ADA187555

Report Date : 08 Aug 1986

Pagination or Media Count : 40

Abstract : One of the main causes of death following traumatic injury has been hemorrhagic shock. Based on numerous studies in animal models and in burn shock patients, there has been considerable interest in evaluating the efficacy of hypertonic sodium chloride solutions in the resuscitation for traumatic injury. The purpose of this contract was to test the hypothesis that 3% sodium chloride will 1) successfully resuscitate hemodynamically unstable patients who have been subjected to major trauma; and 2) will achieve this resuscitation with infusion of smaller volumes of solution than required by patients resuscitated with standard isotonic solutions. Based on the promising work with hypertonic solutions in animal models of shock, this study was begun as a means of obtaining clinical experience in patients undergoing operative repair of traumatic injuries. Keywords: Systolic blood pressure; Heart rate; Urine output; Patients; Survival Shock; Trauma; Blood replacement; Pulmonary function; Crystalloid solutions.

Descriptors :   *HEMORRHAGIC SHOCK, *HYPERTONIC, *RESUSCITATION, *SODIUM CHLORIDE, *SALINE SOLUTION, ANIMALS, BURNS(INJURIES), MODELS, PATIENTS, SHOCK(PATHOLOGY), SOLUTIONS(MIXTURES), TRAUMA, WOUNDS AND INJURIES, EMERGENCIES, THERAPY, PARENTERAL INFUSIONS

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE