Accession Number : ADA187897

Title :   Role of Adenosine Analogs and Growth Hormone in Waking and Sleep.

Descriptive Note : Annual rept. 15 Sep 86-15 Sep 87,

Corporate Author : ILLINOIS UNIV AT THE MEDICAL CENTER CHICAGO COLL OF MEDICINE

Personal Author(s) : Radulovacki, Miodrag

PDF Url : ADA187897

Report Date : 16 Oct 1987

Pagination or Media Count : 5

Abstract : The role of adenosine in sleep has been further investigated using electroencephalography to document the dose response effects of newly developed specific adenosine A1 and A2 receptor stimulants and 8-cyclopropyltheophylline (CPRT), a substituted xanthine. The results with adenosine agonist suggest that both A1 and A2 receptors play a role in the hypnotic action of adenosine. The data with CPRT point out that stimulant effects of xanthines is obtained by the blockade of A1 receptors. Densensitization of adenosine A2 receptors was found following the chronic treatment of adenosine agonists L-PIA, NECA ad deoxycoformycim. Chronic administration of caffeine up-regulates A1 receptors in cerebral cortex in a manner similar to that following deprivation of REM sleep. This suggests the existence of an endocaffeine whose normal role is to block adenosine receptors during prolonged sleep deprivation- a mechanism that could be responsible for the increased number of adenosine receptors. Keywords: Hypnosis; Physiological effects; Sleep deprivation.

Descriptors :   *ADENOSINE, *GROWTH SUBSTANCES, *HORMONES, *SLEEP DEPRIVATION, ANALOGS, CEREBRAL CORTEX, DOSAGE, ELECTROENCEPHALOGRAPHY, HYPNOSIS, HYPNOTICS AND SEDATIVES, PHYSIOLOGICAL EFFECTS, RESPONSE(BIOLOGY), SLEEP, CAFFEINE, BIOLOGICAL RHYTHMS

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE