Accession Number : ADA187950

Title :   Testing of Compounds for Efficacy against Schistosomiasis.

Descriptive Note : Annual summary rept. 15 Aug 86-15 Aug 87,

Corporate Author : LOWELL UNIV MA CENTER FOR TROPICAL DISEASES

Personal Author(s) : Bruce, John I

PDF Url : ADA187950

Report Date : 25 Aug 1987

Pagination or Media Count : 106

Abstract : A total of 19 candidate compounds were tested for prophylactic activity in mice and hamsters. Two of these compounds (Zm65703 and BC78878) were studied and are not recommended for further evaluation as prophylactic candidate drugs. Of the remaining 17 compounds One (BL23702) was found to be highly active, with a protection level of 99.5% Only 2 worms (1 male and 1 female found in separate mice) were found during perfusion of the group of 10 treated mice which received a single dose of 100 mg/kg of drug for 5 consecutive days. No gross toxicity was observed for this compound. This drug is now being studied at an advanced test level in primates. Three other compounds (BL23695, BL23677 and BL23510) gave protection levels against S. mansoni (Kenyan strain) ranging from 91.0% to 94.9% respectively. For each of the mice treated with these compounds, mature adult male and female worms capable of depositing eggs in tissue, and thus causing pathology, were found. At the present time, no further studies on these compounds are contemplated.

Descriptors :   *SCHISTOSOMIASIS, *ANTIPARASITIC DRUGS, ADULTS, DOSAGE, DRUGS, EGGS, FEMALES, HAMSTERS, MALES, MICE, PATHOLOGY, PERFUSION, PREVENTIVE MEDICINE, PRIMATES, PROTECTION, TOXICITY, WORMS, THERAPY, RESISTANCE(BIOLOGY), SCHISTOSOMA MANSONI

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE