Accession Number : ADA188009

Title :   Carbamates, Atropine, and Diazepam: Effects on Performance in the Running Rat,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Matthew, Candace B ; Hubbard, Roger W ; Francesconi, Ralph P ; Thomas, Glenn J

PDF Url : ADA188009

Report Date : 21 Oct 1987

Pagination or Media Count : 9

Abstract : We have reported that when rats (500 g, male) are exercised to exhaustion on a treadmill, pretreatment with the centrally acting carbamate physostigmine reduced endurance (run time, RT) an increased the rate of rise of core temperature (Tc+). Both RT and Tc+ were restored to control levels by pretreatment with either or a combination of atropine (A), and diazepam (D). Our objective in the present work was to determine whether A+D could also restore the performance and thermoregulatory decrements induced by the peripherally acting carbamate pyridostigmine (PY). After drug administration, rats were run (11m/min, 60 elevation, Ta= 26 C) to exhaustion. PY treatment resulted in a reduced RT and an increased heat gain that neither A nor D alone (A+PY and D+PY) could restore to control levels. On the other hand, a combination of both A and D restored these variables to control levels. On the other hand, a combination of both A and D restored these variables to control levels. In conclusion, A+D can restore the performance and thermoregulatory decrements resulting from the administration of either a centrally or a peripherally acting carbamate. Keywords: Carbamates, Atropine, Diazepam, Performance, Anticholinergic anticholinesterase, Animal, Hyperthermia, Anticonvulsant.

Descriptors :   *ATROPINE, *CARBAMATES, *DIAZEPAM, *ENDURANCE(PHYSIOLOGY), ANTICONVULSANTS, CHOLINESTERASE INHIBITORS, CONTROL, CORES, DRUGS, HEAT, HYPERTHERMIA, PHYSOSTIGMINE, RATS, TEMPERATURE, VARIABLES, HEAT, BODY TEMPERATURE, STRESS(PHYSIOLOGY), EXERCISE(PHYSIOLOGY)

Subject Categories : Pharmacology
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE