Accession Number : ADA188115

Title :   Psychophysical, Biochemical and Histological Studies of Spectrally Selective Photic Damage to Primate Retina.

Descriptive Note : Annual rept., Final rept. 1 Nov 82-1 Feb 87,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s) : Sperling, H G ; Wright, A A

PDF Url : ADA188115

Report Date : 25 Feb 1987

Pagination or Media Count : 38

Abstract : Spectral sensitivity and hue discrimination data are presented which show an irrecoverable loss of blue sensitive cone (B-cone) response following as little as 64. milliwatts per cm2 of 458.5nm argon-ion laser exposure to rhesus monkey central retina over 4 hours of intermittent exposure. If reciprocity of intensity and exposure is linear, blue-blindness and attendant loss of discrimination colored signals could result from fewer than 240 brief exposures to blue laser light over a several hour period. Evidence is also shown for green lights. During the current contract period, success was obtained in destroying the B-cone response in single sessions under anaesthesia and in obtaining spectral sensitivity measures from the focal ERG which are sufficiently stable and detailed to measure the response of R-, G- and B-cones, rods and the interactions between them. Evidence is presented, from the focal ERG, that the color-opponent type neural inhibition exists in rhesus, as in fish and amphibia, in the out-plexiform layer of the retina, since it is detectable in the late receptor potential (a-wave). Keywords, Spectral sensitivity; Hue discrimination; Argon-ion laser light, Anaesthesia; Retina.

Descriptors :   *RETINA, *LASER DAMAGE, *LASER HAZARDS, AMPHIBIANS, ARGON LASERS, BLUE(COLOR), COLORS, DISCRIMINATION, HISTOLOGY, IONS, LASER BEAMS, PRIMATES, SENSE ORGANS, SENSITIVITY, SIGNALS, SPECTRA, IRRADIATION, EXPOSURE(PHYSIOLOGY), ANESTHESIA, BLINDNESS

Subject Categories : Radiobiology
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE