Accession Number : ADA188514

Title :   Nerve Growth Factor Effects on the Immune System.

Descriptive Note : Annual rept. Apr-Nov 87,

Corporate Author : TEXAS UNIV MEDICAL BRANCH AT GALVESTON

Personal Author(s) : Perez-Polo, J R

PDF Url : ADA188514

Report Date : 01 Dec 1987

Pagination or Media Count : 5

Abstract : The nerve growth factor protein, NGF, has been shown to play a physiologic role in the development and regeneration of the peripheral nervous system, acting on sensory and sympathetic ganglia. In the central nervous system, NGF induces choline acetyltransferase in certain cholinergic regions and spares magnocellular neurons following fimbria transections. NGF has been shown to act in vivo on non-neuronal tissues as a modular of immune and inflammatory reactivity. We have demonstrated the presence of receptors to NGF on rat and human mononuclear cells and the specific and saturable binding of NGF to these cells. Our data is consistent with the hypothesis that NGF effects on tissues are important to differentiation of these tissues. also, that NGF receptors on different tissues are slightly different structurally although the NGF binding properties are very similar. Keywords: Cultures(Biology); Interleukins; Lectins.

Descriptors :   *NERVES, *PROTEINS, *GROWTH SUBSTANCES, *IMMUNOCHEMISTRY, CHOLINERGIC NERVES, CHOLINES, GANGLIA, GROWTH(GENERAL), IMMUNITY, INFLAMMATION, NERVOUS SYSTEM, PERIPHERAL NERVOUS SYSTEM, PHYSIOLOGY, RATS, REACTIVITIES, SYMPATHETIC NERVOUS SYSTEM, GROWTH(PHYSIOLOGY), CULTURES(BIOLOGY), RESPONSE(BIOLOGY), MITOSIS, LYMPHOCYTES

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE