Accession Number : ADA188517

Title :   Trimer of 15-Dehydro-PGB1 Improves Recovery of Mitochondrial Function after Renal Ischemia.

Descriptive Note : Annual rept. Dec 86-Nov 87,

Corporate Author : OREGON HEALTH SCIENCES UNIV PORTLAND

Personal Author(s) : Widener, Linda L ; Bartos, Dagmar ; Mela-Riker, Leena

PDF Url : ADA188517

Report Date : 30 Nov 1987

Pagination or Media Count : 4

Abstract : The efficacy of (PGB1)3 in protecting renal mitochondrial function from ischemic reperfusion injury was firmly established in a series of experiments in rats. Renal ischemia was induced by unilaterial closure of the renal artery with an arterial clip. After 48 minutes of ischemia the clip was opened to recover blood flow. At this time treated animals were given a bolus injection, I.P., of 2.5 mg/kg (PGB1)3. Sham controls received an injection of the vehicle. The animals were sacrificed 24 hours later, renal mitochondria were isolated and their function analyzed. Our data indicate that a bolus injection of (PGB1) 3 given at the time of reflow provides significant improvement of mitochondrial function after 48 minutes of renal ischemia in the rat.

Descriptors :   *ISCHEMIA, *KIDNEYS, *MITOCHONDRIA, *PROSTAGLANDIN, ARTERIES, BLOOD CIRCULATION, FLOW, RATS, RECOVERY, REPRINTS, TIME, TRAUMATIC SHOCK, WOUNDS AND INJURIES, THERAPY, INJECTIONS(MEDICINE)

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE