Accession Number : ADA188697

Title :   Effects of Chronic Pyridostigmine Administration on Muscle Fatigue and Morphology.

Descriptive Note : Final rept. 15 Nov 83-14 Nov 84,

Corporate Author : HADASSAH MEDICAL ORGANIZATION JERUSALEM (ISRAEL) DEPT OF NEUROLOGY

Personal Author(s) : Fishman, Rachelle H ; Abramsky, Oded ; Argov, Zohar ; Chipman, Martin

PDF Url : ADA188697

Report Date : Jul 1987

Pagination or Media Count : 92

Abstract : Pyridostigmine, a reversible anticholinesterase is used prophylactically against subsequent exposure to organophosphates. Yet, there is evidence from animal studies that reversible anticholinesterase agents can induce structural and functional abnormalities in the neuromuscular system. The damage appears to require a threshold exposure in time and dose, and can be prevented by prior denervation of the muscle, implying that the origin of the damage stems from the extended presence of acetylcholine (ACh) released into the neuromuscular junction from the presynaptic nerve, resulting in excessive activation of proteases by the influx of calcium at the motor endplate.

Descriptors :   *CHOLINESTERASE INHIBITORS, *FATIGUE, *MORPHOLOGY(BIOLOGY), ABNORMALITIES, ACETYLCHOLINE, ACTIVATION, ANIMALS, CALCIUM, JUNCTIONS, MUSCLES, NERVES, ORGANOPHOSPHATES, PEPTIDE HYDROLASES, REVERSIBLE, STRUCTURAL PROPERTIES, THRESHOLD EFFECTS, EXPOSURE(PHYSIOLOGY), RESPONSE(BIOLOGY), PHYSIOLOGICAL EFFECTS, NERVE CELLS, NERVE TRANSMISSION

Subject Categories : Pharmacology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE