Accession Number : ADA189001

Title :   Mutagenic Potential of Nitrosoguanidine in the Mouse Lymphoma Forward Mutation Assay.

Descriptive Note : Final rept. 22 Sep-18 Nov 86,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Harbell, John W. ; Korte, Don W., Jr

Report Date : DEC 1987

Pagination or Media Count : 36

Abstract : The mutagenic potential of nitrosoguanidine (TP048) was assessed in the mouse lymphoma thymidine kinase forward mutation assay both with and without metabolic activation by rat liver S-9. In the initial and confirmatory assays, cells were exposed to test compound concentrations ranging from 1.5 mg/ml to 0.7 mg/ml. Nitrosoguanidine induced a significant increase in the mutant frequency in both assays. These results indicate that nitrosoguanidine was mutagenic under the conditions of this study. Keywords: Mutagenicity, Genetic toxicology, Mouse lymphoma assay, Nitrosoguanidine, Cytotoxicity, Propellants, Environmental hazards, Health hazards.

Descriptors :   *PROPELLANTS, *TOXICOLOGY, *MUTAGENS, ACTIVATION, ENVIRONMENTS, FREQUENCY, GENETICS, HEALTH, LYMPHOMAS, METABOLISM, MICE, MUTATIONS, BIOASSAY, RESPONSE(BIOLOGY), PHYSIOLOGICAL EFFECTS, TOXIC HAZARDS, NITROGUANIDINE.

Subject Categories : Environmental Health and Safety
      Toxicology
      Solid Rocket Propellants

Distribution Statement : APPROVED FOR PUBLIC RELEASE