Accession Number : ADA189117

Title :   The Neurotrophic Substances and Behavioral Recovery from Brain Damage.

Descriptive Note : Annual rept. 15 Jul 83-30 Sep 84; Final rept. 15 Jul 82-30 Sep 84,

Corporate Author : CLARK UNIV WORCESTER MA

Personal Author(s) : Stein, Donald G

PDF Url : ADA189117

Report Date : Nov 1984

Pagination or Media Count : 110

Abstract : Recent developments in neuroscience research have shown that neurotrophic substances, both endogenous and systematically administered, may play an important role in mediating functional recovery from traumatic injuries to the central nervous system and spinal cord. In our laboratory, we have been able to demonstrate that intracerebrally administered Nerve Growth Factor (NGF) and systemically administered gangliosides (GM-1) can markedly improve post-traumatic performance in brain-damaged, adult rats. In contrast, polyamine administration was not effective when given to adult, brain-injured subjects. In addition, we have shown that transplants of fetal brain tissue into damaged, adult, host brains can attenuate the symptoms produced by the brain lesions and that the transplants form anatomical connectors with the host brain. I proposed to use both behavioral and anatomical techniques to continue and extend research on the role of neurotrophic substances, including brain transplants, in mediating functional recovery from brain injuries. Specifically, I proposed to examine whether: there are long-lasting effects of repeated injections of neurotrophic substances such as NGF and GM-1; treatments can be given at various times after injury is sustained and still be effective in promoting functional recovery; combinations of neurotrophic substances can be given to enhance the recovery process.

Descriptors :   *BRAIN DAMAGE, *NERVE CELLS, *GROWTH SUBSTANCES, ADULTS, AMINES, ANATOMY, BEHAVIOR, BRAIN, CENTRAL NERVOUS SYSTEM, CONNECTORS, FETUS, LESIONS, LONG RANGE(TIME), NERVES, RATS, RECOVERY, SIGNS AND SYMPTOMS, SPINAL CORD, TISSUES(BIOLOGY), TRAUMATIC SHOCK, GROWTH(PHYSIOLOGY), SURGICAL TRANSPLANTATION, CHEMOTHERAPY

Subject Categories : Pharmacology
      Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE