Accession Number : ADA189133

Title :   Fundamental Studies in the Molecular Basis of Laser Induced Retinal Damage.

Descriptive Note : Annual rept. Sep 83-Sep 84,

Corporate Author : CORNELL UNIV ITHACA NY SCHOOL OF APPLIED AND ENGINEERING PHYSICS

Personal Author(s) : Lewis, Aaron

PDF Url : ADA189133

Report Date : Sep 1984

Pagination or Media Count : 77

Abstract : In this section we will describe advances made in our work for the Ocular Hazards Program at the Letterman Army Institute of Research (LAIR). Our research has seen the first application of femtosecond lasers to the visual system. This research is giving new insights into how these ultimate laser sources interact with biological tissue in general and with the visual system in particular. We have discovered that simple anions can activate visual photoreceptors in the dark. Among these anionic activators is the dental agent fluoride. We have continued our research into identifying selectively and spatially the image of various elements in photoreceptors and adjacent tissue. We were able to extend our preparation procedures to view the elemental composition of such components as melanin granules. The sensitive and selective spatial images we are getting should play important roles in extending our understanding of the fundamental mechanisms of laser damage. The staining procedures we have developed can be applied to study laser damaged retina. We have obtained data demonstrating rapid mechanical motions in vertebrate photoreceptors. Such rapid mechanical motions which parallel electrophysiological responses in the cell may lie at the very basis of photoreceptor function. Laser damage mechanisms we believe should now be reevaluated in terms of this new data. The effect of laser light on these newly discovered mechanical motions will surely lead to new and improved understanding of low level laser ocular hazards.

Descriptors :   *LASER DAMAGE, *RETINA, ACTIVATION, ANIONS, DAMAGE, DENTISTRY, ELECTROPHYSIOLOGY, EYE, FLUORIDES, GRANULES, IMAGES, LASER BEAMS, LASERS, MELANIN, MOTION, PARALLEL ORIENTATION, PHOTORECEPTORS, PREPARATION, RESPONSE(BIOLOGY), SENSITIVITY, SOURCES, SPATIAL DISTRIBUTION, TISSUES(BIOLOGY), VERTEBRATES, VISION, LASER HAZARDS, BIOMOLECULES

Subject Categories : Stress Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE