Accession Number : ADA189145

Title :   Studies of the Biology of Phleboviruses in Sandflies.

Descriptive Note : Final rept. 1 Sep 80-18 May 87, annual rept. 1 Feb-9 Dec 86,

Corporate Author : YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE

Personal Author(s) : Tesh, Robert B

PDF Url : ADA189145

Report Date : 31 Aug 1987

Pagination or Media Count : 45

Abstract : Investigations were carried out on the biology of phlebotomus fever group viruses (Bunyaviridae: Phlebovirus) in their sandfly vectors. This work included studies on the susceptibility of sandflies to oral and parenteral infection with phleboviruses, replication of the viruses in the insects, and the ability of these agents to be vertically transmitted in their vectors. In addition, a number of sandfly species were colonized for the first time, and two continuous sandfly cell cultures were established. Results of these studies suggest some phleboviruses are maintained in nature by two mechanisms: vertical (transovarial) transmission in their insect vector and an alternating mammal-insect cycle. Keywords: Virus diseases; Disease vectors; Entomology; Transmittance; Cultures(Biology); Cells(Biology).

Descriptors :   *DISEASE VECTORS, *SANDFLY FEVER VIRUS INFECTION, *ARBOVIRUSES, BIOLOGY, CELLS(BIOLOGY), CULTURES(BIOLOGY), DIPTERA, ENTOMOLOGY, INFECTIOUS DISEASES, INSECTS, PARENTERAL INFUSIONS, VIRUS DISEASES, VIRUSES

Subject Categories : Microbiology
      Medicine and Medical Research
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE