Accession Number : ADA189292

Title :   Teratogenic Potential of Ethylene Thiourea (ETU), A Positive Control in Sprague-Dawley Rats.

Descriptive Note : Rept. for 31 Aug 82-15 Mar 83,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Coppes, Valerie G ; Hanes, Martha A ; Korte, Don W , Jr

PDF Url : ADA189292

Report Date : Oct 1987

Pagination or Media Count : 81

Abstract : The teratogenic potential of ethylene thiourea (ETU) was tested in pregnant Sprague-Dawley rats. An aqueous solution of ETU was administered by oral gavage at a dose level of 40 mg/kg on Days 6 through 15 of gestation. Fetuses were delivered by cesarean section on Day 20, weighed, examined externally, and either processed in Bouin's solution for visceral examination or alizarin red stain for skeletal examination. ETU produced teratogenic and embroyotoxic effects in Sprague-Dawley rats. The purpose of this study was to provide historic data demonstrating the Sprague-Dawley rat is sensitive to a known teratogen in the LAIR teratogenicity test system.

Descriptors :   *ETHYLENE, *TERATOGENIC COMPOUNDS, *THIOUREA, *TOXICITY, *CONGENITAL ABNORMALITIES, DOSAGE, FETUS, PREGNANCY, RATS, SOLUTIONS(MIXTURES), TOXICOLOGY, TOXIC TOLERANCES, BODY WEIGHT

Subject Categories : Toxicology
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE