Accession Number : ADA189357

Title :   Stability of T-2, HT-2, and T-2 Tetraol in Biological Fluids.

Descriptive Note : Progress rept.,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Pace, Judith G. ; Matson, Charles F.

PDF Url : ADA189357

Report Date : 01 APR 1987

Pagination or Media Count : 11

Abstract : The present study defines how biological samples should be collected and stored for the most accurate analysis of T-2 toxin and its metabolites. T-2 toxin was stable in blood and urine if stored in the presence of sodium fluoride at -70 C. The degradation products most likely to be detected in blood samples collected and stored under adverse conditions were HT-2 and T-2 tetraol. In vivo, T-2 mycotoxin is rapidly metabolized to more-polar metabolites. T-2 tetraol is a major metabolite found in excreta of animals after exposure of T-2 toxin by parenteral or dermal routes. Our data showed T-2 tetraol to be the most stable metabolite and, therefore, the most appropriate metabolite for diagnostic testing.

Descriptors :   *BLOOD, *METABOLITES, *URINE, *PHYTOTOXINS, ANIMALS, BIOLOGY, EXCRETION, FLUORIDES, IN VIVO ANALYSIS, SAMPLING, SODIUM, STABILITY, TEST AND EVALUATION, LABELED SUBSTANCES, TRITIATED COMPOUNDS, BLOOD STORAGE, COLLECTING METHODS, DIAGNOSIS(MEDICINE), STORAGE, BLOOD PRESERVATION.

Subject Categories : Medicine and Medical Research
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE