Accession Number : ADA189400

Title :   Heat Exchange Through Cutaneous Vasolidation after Atropine Treatment in a Cool Environment,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Kolka, Margaret A ; Stephenson, Lou A

PDF Url : ADA189400

Report Date : Oct 1987

Pagination or Media Count : 21

Abstract : This report summarizes a tightly controlled laboratory study in which the thermoregulatory effects of an intramuscular injection of atropine sulfate were compared with a placebo injection of sterile saline during exposure to a cool environment. Four subjects were tested during seated cycle exercise at a moderate exercise intensity. The expected decrease in whole body and local sweating rate occurred in the atropine treated subjects. By 10-15 min of exercise, radiative and convective heat exchange was significantly elevated from the head, chest, back, arm, forearm and thigh in the atropine experiments. Core temperature actually decreased 0.2 C in the atropine treated subjects during exercise as a result of enhanced dry heat exchange. By 25 min of exercise, Skin blood flow (FBF) was 98% greater after atropine treatment. These results show that the peripheral modification of cutaneous blood flow which occurs in atropine treated subjects is sufficient to markedly alter heat exchange in a cool environment. Keywords: Anticholinergic, Dry heat exchange, Sweating, Thermoregulation, Vasodilation.

Descriptors :   *ATROPINE, *BLOOD CIRCULATION, *INTRAMUSCULAR INJECTIONS, *SKIN(ANATOMY), *VASODILATION, CONVECTION(HEAT TRANSFER), COOLING, CYCLES, EXERCISE(PHYSIOLOGY), LOW HUMIDITY, PLACEBOS, RADIANT HEATING, SULFATES, TEMPERATURE CONTROL

Subject Categories : Pharmacology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE