Accession Number : ADA189403

Title :   The Blood Volume of the Guinea Pig: Effects of Epinephrine and Isoproterenol upon the Red Cell and Plasma Volumes, Heart Rate, and Mean Arterial Pressure,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Millnamow, Gregory A

PDF Url : ADA189403

Report Date : Sep 1987

Pagination or Media Count : 84

Abstract : In the present study, the blood volume of the guinea pig was assessed by direct measures of Hct and dilution samples of autologous red blood cells labeled with sodium chromate. In addition, experimental measures were performed following the administration of the sympathomimetic catecholamine epinephrine to assess the potential influence of splenic mobilization of red cells upon the circulating mass. Doses were selected to elicit maximum contraction of the splenic smooth muscle and discharge of red blood cells. Isoproterenol was administered in identical doses to a separate set of subjects to assess the pharmacological effects of this potent cardiovascular stimulant upon the circulating blood volume. Mean arterial pressure (MAP) and heart rate (HR) were monitored to assess the hemodynamic responses of the system to these agonists. Likewise, measures were performed upon splenectomized individuals for comparison of the systemic effects of the catecholamines.

Descriptors :   *BLOOD VOLUME, *EPINEPHRINE, *ERYTHROCYTES, *ISOPROTERENOL, BLOOD CIRCULATION, BLOOD PLASMA, BLOOD PRESSURE, CATECHOLAMINES, CHROMATES, DOSAGE, GUINEA PIGS, HEART RATE, MUSCLES, PHARMACOLOGY, SODIUM, SPLEEN, LABELED SUBSTANCES, HEMATOLOGY

Subject Categories : Pharmacology
      Anatomy and Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE