Accession Number : ADA189622

Title :   Teratogenic Potential of 4-Nitrophenyl Methyl Phenyl Phosphinate (MPP) in Rats.

Descriptive Note : Rept. for 31 Aug 82-15 Mar 83,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Coppes, Valerie G ; Hanes, Martha A ; Korte, Don W , Jr

PDF Url : ADA189622

Report Date : Oct 1987

Pagination or Media Count : 92

Abstract : The teratogenic potential of 4 nitrophenyl methyl phenyl phosphinate (MPP) was tested in pregnant Sprague Dawley rats. MPP was administered by oral gavage on Days 6 through 15 of gestation. Dose levels tested were 0,0.12, 1.25, and 3.12 mg/kg/day. The vehicle contained 21.5 Tween 80, 18.5% absolute ethanol, 37.5% 50 mM citrate buffer, and 22.5% distilled water. Fetuses were delivered by cesarean section on Day 20 and weighed, examined externally, and either processed Bouin's solution for visceral examination or alizarin red stain for skeletal examination. MPP did not produce dose-related teratogenic or embryotoxic effects in Sprague Dawley rats. Keywords: Developmental Toxicology, Teratology, 4 Nitrophenyl methyl phenyl phosphinate, Rats, Phosphinates, Methyl radicals.

Descriptors :   *PHOSPHINATES, *TOXICOLOGY, *TERATOGENIC COMPOUNDS, DOSAGE, LEVEL(QUANTITY), METHYL RADICALS, RATS, TOXIC TOLERANCES, RESPONSE(BIOLOGY), PHYSIOLOGICAL EFFECTS, NITRO RADICALS, PHENYL RADICALS

Subject Categories : Pharmacology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE