Accession Number : ADA189771

Title :   A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma.

Descriptive Note : Annual rept. Sep 82-Sep 84,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Wilmore, Douglas

PDF Url : ADA189771

Report Date : 06 Dec 1987

Pagination or Media Count : 42

Abstract : The purpose of this work was to attenuate skeletal muscle proteolysis in the post-traumatic period. In the initial study, amino acid solutions were administered with or without glutamine supplementation. Amino Acid administration at the dose of 0.624 grams nitrogen kg hour was associated with near nitrogen balance, maintenance of skeletal muscle intracellular stores, and attenuation of hind-quarter nitrogen loss. In additional studies, adrenergic blockade was achieved by administering phentolamine and propranolol or utilizing high epidural anesthesia. While blockade did not reduce nitrogen excretion in the posttraumatic period, nitrogen efflux from the hind-quarter was markedly attenuated. This is the first demonstration of a relationship between the adrenergic nervous system and accelerated proteolysis. The significance of these findings is discussed.

Descriptors :   *MUSCLE PROTEINS, *CATABOLISM, AMINO ACIDS, ATTENUATION, BALANCE, DEMONSTRATIONS, EPINEPHRINE, GLUTAMINE, LOSSES, NERVE BLOCKING, NERVOUS SYSTEM, NITROGEN, SYMPATHETIC NERVOUS SYSTEM, SYMPATHOLYTIC AGENTS, PHYSIOLOGICAL EFFECTS, MUSCLE FIBERS, RESPONSE(BIOLOGY), TRAUMA, SOLUTIONS(MIXTURES), LYSIS, STRESS(PHYSIOLOGY)

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE