Accession Number : ADA189938

Title :   Teratogenicity, Mutagenicity, and Effects of Grade 2 Diesel Fuel on Reproduction in a Single Generation of Rats.

Descriptive Note : Technical rept. Oct 79-Jul 80,

Corporate Author : CHEMICAL RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD

Personal Author(s) : Starke, William C ; Pellerin, Ronald J ; Burnett, David C ; Manthei, James H ; Heitkamp, Dale H

PDF Url : ADA189938

Report Date : Oct 1987

Pagination or Media Count : 28

Abstract : Pregnant dams were exposed to DF-2 smoke, of tank exhaust for 1 hr and to noise from the tank's engine for 20-30 sec. One litter in the DF-2 smoke group had three fetuses with major, gross malformations and two with visceral abnormalities. The DF-2 smoke group also showed the greatest number of fetuses with sites of low bone ossification. Males in the DLM study and the males and females in the single generation (SG) reproduction study were exposed to DF-2 smoke or exhaust for 15 or 60 min. Unexposed dams were mated to DLM males from the 15-min exhaust group during the males' second week of post-exposure. These females had significantly more resorptions than the noise controls for the same mating period. The major malformations observed in the teratology study occurred in rather isolated instances. Retarded bone ossification was indicated in the DF-2 smoke group but without significantly lower body weights. Nothing indicates that DF-2 smoke caused fetal growth retardation. Observances in the DLM study were not strong enough to suspect a mutational effect, and the observations in the SG study gave no support for adverse effects on reproduction.

Descriptors :   *DIESEL FUELS, *REPRODUCTION(PHYSIOLOGY), *MUTAGENS, *CONGENITAL ABNORMALITIES, *SMOKE, ABNORMALITIES, ABSORPTION, BODY WEIGHT, FEMALES, FETUS, MALES, NOISE, ORGANS(ANATOMY), PREGNANCY, RATS, RETARDATION, TERATOGENIC COMPOUNDS, MUTATIONS, GROWTH(PHYSIOLOGY), TANK ENGINES, EXHAUST GASES

Subject Categories : Toxicology
      Air Pollution and Control
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE