Accession Number : ADA190154

Title :   Beneficial Effect of Dexamethasone in Decreasing the Lethality of Acute T-2 Toxicosis,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Fricke, Robert F.

PDF Url : ADA190154

Report Date : 07 NOV 1986

Pagination or Media Count : 23

Abstract : Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicyclic acid, were either ineffective, or potentiated the lethality of T-2 toxin. Steroidal agents, assessed at equivalent doses for anti-inflammatory activity, were all effective, with dexamethasone being more effective than either methylprednisolone or hydrocortisone. The doses of dexamethasone producing the highest efficacy were 1.0 mg/kg and 12.5 mg/kg for im and ip routes of administration, respectively. The mean time to death, mean survival time, and percent lethality were determined for untreated and dexamethasone-treated mice injected with a lethal dose of T-2 toxin.

Descriptors :   *PHYTOTOXINS, *TOXINS AND ANTITOXINS, *ANTIINFLAMMATORY AGENTS, ANALGESICS, DEATH, DOSAGE, LETHAL DOSAGE, LETHALITY, MEAN, MICE, SURVIVAL(GENERAL), TIME, STEROIDS, FUSARIUM.

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE