Accession Number : ADA190177

Title :   Effect of Chloroquine on the Toxicity in Mice of the Venom and Neurotoxins from the Snake Bungarus multicinctus,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Crosland, Richard D.

Report Date : 08 OCT 1987

Pagination or Media Count : 21

Abstract : Antivenoms are the currently available agents for treatment of snake venom intoxication in humans. The development of therapeutic strategies employing more generally available drugs could improve treatment of invenomation by reducing hypersensitive reactions, cost and storage requirements. I report that chloroquine reduced the toxicity in mice of the venom and drug were administered krait, Bungarus multicinctus, when both venom and drug were administered i.p. When chloroquine was injected immediately after the injection of venom, the LD50 of the venom was increased fivefold from 19 micrograms/kilogram to 95 micrograms/kilogram. Investigation of chloroquine's effect on the purified neurotoxic components of B. Multicinctus venom revealed that chloroquine increased the LD50 of B-bungarotoxin 17 fold, form, 7.8 micrograms/kilogram to 134 micrograms/kilogram, but has little effect on the LD50 of a-bungarotoxin. Chloroquine was an effective antagonist of the toxicity of B. multicinctus venom and of purified BETA-bungarotoxin without itself being overtly toxic. Keywords: Presynaptic Neurotoxins.

Descriptors :   *CHLOROQUINE, *TOXICITY, *TOXINS AND ANTITOXINS, *VENOMS, *SNAKES, CHEMOTHERAPEUTIC AGENTS, DRUGS, HUMANS, INJECTION, INTOXICATION, MICE, NERVOUS SYSTEM, REQUIREMENTS, SNAKES, STORAGE, STRATEGY, ANTIDOTES.

Subject Categories : Toxicology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE