Accession Number : ADA190250

Title :   The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.

Descriptive Note : Annual rept. 1 Jul 83-30 Jun 84,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Carey, Michael E

PDF Url : ADA190250

Report Date : 15 Sep 1984

Pagination or Media Count : 24

Abstract : We have developed an experimental gun to inflict a precise transcranial missile wound to the brain of a cat. The missile is a 30 mg steel sphere which optimally deposits 1.3 Joules of energy in the right cerebral hemisphere. After wounding, a breakdown of the blood-brain barrier occurs and alterations of the brain water sodium and potassium are seen. Immediately after missile impact arterial hypertension and bradycardia ensue. Respiratory abnormalities also occur. Wounds of 1.8 Joules or greater cause immediate respiratory arrest and sometimes cause brain stem hemorrhages. Keywords: Brain damage, Wounds and Injuries, Response(Biology).

Descriptors :   *BRAIN DAMAGE, *BULLET WOUNDS, *CATS, ABNORMALITIES, ARTERIES, BLOOD, BLOOD CIRCULATION, BRADYCARDIA, BRAIN, CEREBRUM, ELECTROLYTES, GUNS, HEMISPHERES, HEMORRHAGE, HYPERTENSION, IMPACT, PERMEABILITY, POTASSIUM, RESPIRATORY SYSTEM, SODIUM, WATER, RESPONSE(BIOLOGY)

Subject Categories : Weapons Effects(biological)

Distribution Statement : APPROVED FOR PUBLIC RELEASE