Accession Number : ADA190302

Title :   Three Proteins Made by Glial Cells of the Goldfish (C. auratus) Optic Nerve Undergo Increased Synthesis Following Trauma to the Optic Nerve.

Descriptive Note : Rept. for Sep 86-Jun 87,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Deaton, Michael A ; Bock, Susan E ; Freeman, John ; Zqick, Harry

PDF Url : ADA190302

Report Date : Nov 1987

Pagination or Media Count : 14

Abstract : Glial cells have been shown to increase the levels of synthesis of selected proteins in response to damage inflicted upon their associated axons. These proteins may be instrumental in mediating axonal repair. In this study proteins synthesized by the glial cells of the goldfish optic nerve were examined using tissue incubation, polyacrylamide gel electrophoresis, and gel fluorography. Ten days after monocular nerve crush or monocular enucleation, three glial proteins were found to have increased levels of synthesis relative to controls. These enhanced glial proteins, or EGPs, were detectably increased relative to controls at 4.5 hr after nerve trauma, and returned to control levels of synthesis by 6 months post-crush. Keywords: Nerve regeneration, Proteins, Glia, Goldfish, Optic nerve, Growth substances.

Descriptors :   *OPTIC NERVE, *PROTEINS, *BIOSYNTHESIS, CONTROL, CRUSHING, DAMAGE, ELECTROPHORESIS, EYE, GELS, GROWTH SUBSTANCES, NERVE FIBERS, NERVES, POLYACRYLAMIDES, REGENERATION(PHYSIOLOGY), REPAIR, TRAUMA, WOUNDS AND INJURIES, RESPONSE(BIOLOGY), BIOCHEMISTRY, WOUNDS AND INJURIES

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE