Accession Number : ADA190612

Title :   Development of a Calcifiable Matrix for Bone Formation.

Descriptive Note : Final rept. 1 May 82-28 Feb 86,

Corporate Author : ALABAMA UNIV IN BIRMINGHAM LAB OF MOLECULAR BIOPHYSICS

Personal Author(s) : Urry, Dan W

PDF Url : ADA190612

Report Date : 01 Sep 1987

Pagination or Media Count : 34

Abstract : As a contractual, development-synthetic effort, this project had two goals. The first was the delivery to the USAIDR of approximately 13 grams of synthetic peptide for in vivo study of calcifiability, ossification, biocompatibility and wound repair issues. The second goal was the characterization of the peptide in matrix form with respect to its in vitro calcification, stress-strain properties, biocompatibility and chemotaxis potential. This project was developmental in nature an objective was the elaboration of an off the shelf matrix for bone formation with the approach being based on a polypentapeptide. This polymer, when cross-linked into an insoluble matrix, calcified massively on exposure to normal human serum dialyzates. Keywords: Peptide synthesis, Sequential polypeptides, Polymerization methods, Y-irradiation cross-linking, Cross-linked polynonapentapeptide, Chemotaxis, Wound cover, Osteogenesis.

Descriptors :   *PEPTIDES, *OSTEOGENESIS, *MATRIX MATERIALS, BLOOD SERUM, BONES, CALCIFICATION, CHEMOTAXIS, HUMANS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, METHODOLOGY, POLYMERIZATION, POLYMERS, REPAIR, SEQUENCES, STRESS STRAIN RELATIONS, WOUNDS AND INJURIES, SYNTHESIS(CHEMISTRY), THERAPY

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE