Accession Number : ADA190770

Title :   Preparation of a Fentanyl Ligand for the Opiate Receptor.

Descriptive Note : Contractor rept. Jun-Sep 86,

Corporate Author : PITTSBURGH UNIV PA SCHOOL OF MEDICINE

Personal Author(s) : Wingard, Lemuel B , Jr ; Narasimhan, Krishna

PDF Url : ADA190770

Report Date : Nov 1987

Pagination or Media Count : 32

Abstract : The objective of this task was to prepare radiolabeled nd nonradiolabeled photo-affinity label fentanyl derivative, propanamide. The compound was prepared for use by the U.S. Army in the study of opiate receptors. Several grams of the nonlabeled and a few micrograms of the radio-labeled analog were synthesized. The route of the synthesis was first worked out using nonradiolabeled compounds. The addition of the radiolabel ws incorporated as the final step in the synthesis. Alternate purification methods need to be considered for optimization of the yield of pure radiolabeled product. Keywords: Synthesis(Chemistry), Radiolabeled substances, Photoaffinity label, Organic synthesis, Opiate receptor ligand.

Descriptors :   *LIGANDS, *AMIDES, *SYNTHESIS(CHEMISTRY), LABELED SUBSTANCES, METHODOLOGY, OPIUM ALKALOIDS, OPTIMIZATION, PURIFICATION, PURITY, RADIOACTIVE ISOTOPES, SENSE ORGANS

Subject Categories : Organic Chemistry
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE