Accession Number : ADA190903

Title :   Development of Microcomputer Methods for Analysis and Simulation of Clinical Pharmacokinetic Data Relevant to New Drug Development.

Descriptive Note : Annual rept. (Final) 1 Nov 79-29 Jul 85,

Corporate Author : DUKE UNIV DURHAM NC DIV OF CLINICAL PHARMACOLOGY

Personal Author(s) : Bjornsson, Thorir D ; Wagoner, Robert

PDF Url : ADA190903

Report Date : 02 Aug 1985

Pagination or Media Count : 20

Abstract : The research proposed under this contract is a feasibility study in the development of applications of new microcomputer graphics technology to the analysis and interpretation of clinical pharmacological data. This involves continuing development of comprehensive programs for analysis, interpretation, and simulation of pharmacokinetic data, dose-response kinetic data, and other data relevant to new drug development, for use with the Tektronix 4052 Microcomputer Graphics System. The combination of such modern analytical and illustrative methods in clinical pharmacology, based on new high-speed microcomputers and associated graphics, are thought to greatly reduce both cost and time involved in the overall process of clinical evaluation of new drugs in the U.S. Army Drug Development Program. The work performed includes the following: Program for Linear Pharmacokinetic Data Analysis by Non-Linear Curve Fitting Using Compulsory Graphics; Program to Simulate Time Courses of Drug Concentrations After Drug Administration, for Any Number of Doses and Route of Administration; Program to Compute the Urinary Excretion Rate Constant of Drugs; Program for Pharmokinetic Parameter Conversion; Statistical Programs for Clinical Pharmacological Problems; Keywords: Clinical Pharmacokinetics, Dose-Response Relations, Pharmakinetic Simulation, Non-Parametric Statistics, Mefloquine, Microcomputer Graphics, Tektronix 4052.

Descriptors :   *CLINICAL MEDICINE, *PHARMACOKINETICS, *MEDICAL COMPUTER APPLICATIONS, *BIOMEDICAL INFORMATION SYSTEMS, CONCENTRATION(CHEMISTRY), CONVERSION, COSTS, CURVE FITTING, DOSAGE, DRUGS, EXCRETION, EXPERIMENTAL DATA, FEASIBILITY STUDIES, KINETICS, MATHEMATICAL ANALYSIS, METHODOLOGY, MICROCOMPUTERS, PHARMACOLOGY, RATES, RESPONSE(BIOLOGY), SIMULATION, STATISTICS, TEST AND EVALUATION, URINE, COMPUTER GRAPHICS, ARMY RESEARCH, COMPUTER PROGRAMS, MILITARY MEDICINE

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE