Accession Number : ADA191002

Title :   Potential Benefits and Hazards of Humoral Immune Reactions against HTLV-III.

Descriptive Note : Annual rept. 30 Sep 86-29 Sep 87,

Corporate Author : KAROLINSKA INST STOCKHOLM (SWEDEN)

Personal Author(s) : Wigzell, Hans ; Gidlund, Magnus ; Nilsson, Kenneth

PDF Url : ADA191002

Report Date : 10 Oct 1987

Pagination or Media Count : 18

Abstract : Gp120 binding to CD4 requires beta-glycanase sensitive carbohydrate chains to retain binding ability. A 28Kd fragment of Gp120 has been identified with complete retention of CD4 binding capacity. Human monocytes can be readily infected with HIV. In the absence of anti-HIV antibodies, phagocytic or non-phagocytic monocytes are equally sensitive. Anti-HIV antibodies at certain high dilutions may enhance HIV proliferation in human monocytes although exact conditions causing such enhancement are not yet defined. Certain human HIV-seropositive individuals produce high titered antibodies which display molecular mimicry with CD4 and bind to Gp120. Such antibodies may tentatively be linked to good prognosis. Keywords: Human immunodeficiency virus, Immunosuppression, Immunity.

Descriptors :   *ANTIBODIES, *IMMUNOSUPPRESSION, *VIRUSES, HAZARDS, HUMANS, HUMORAL IMMUNITY, IMMUNITY, MONOCYTES, PREDICTIONS, PHAGOCYTES, MOLECULE MOLECULE INTERACTIONS, GLYCOPROTEINS, ANTIGENS

Subject Categories : Genetic Engineering and Molecular Biology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE