Accession Number : ADA191238

Title :   Corticosteroid/Antibiotic Treatment of Septic Shock: An Evaluation of Mechanisms.

Descriptive Note : Final annual rept.,

Corporate Author : OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY

Personal Author(s) : Hinshaw, Lerner B

PDF Url : ADA191238

Report Date : 23 Jul 1986

Pagination or Media Count : 27

Abstract : We have succeeded in developing the first effective therapy to prevent death from septic shock induced by a 100% lethal dose of live E. coli organisms administered intravenously to dogs and nonhuman primates. The therapy consists of intermittent infusions of the corticosteroid, methylprednisolone sodium succinate, and the aminoglycoside antibiotic, gentamicin sulfate. Application of the therapy soon after initiation of E. coli administration has increased survival ( 7 days) from 0% to 100% in both dogs and baboons. The purpose of this study was to delineate the exact mechanisms of protection of our corticosteroid/antibiotic therapy, including how it is involved with the cardiovascular, metabolic, endocrinologic and host-defense systems of the septic animal. We have particularly emphasized evaluation of therapy interaction with adrenal cortex, lung, liver, and leukocytes. We have evaluated the roles of granulocytes in tissue injury in live organism-induced shock and assayed the role of corticosteroid in prevention of such injury. We have also assessed the significance of B-endorphin the pathogenesis of shock and effectiveness of therapy.

Descriptors :   *ANTIBIOTICS, *CORTICOSTEROID AGENTS, *SHOCK(PATHOLOGY), *CHEMOTHERAPY, ADRENAL CORTEX, ANIMALS, BABOONS, DEATH, DOGS, ESCHERICHIA COLI, GRANULOCYTES, HOSTS(BIOLOGY), INFUSIONS, INTERACTIONS, LEUKOCYTES, LIVER, LUNG, MICROORGANISMS, PATHOGENESIS, POISONING, PRIMATES, PROTECTION, SHOCK, SULFATES, SURVIVAL(GENERAL), THERAPY, TISSUES(BIOLOGY), WOUNDS AND INJURIES

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE