Accession Number : ADA191301

Title :   Hemorrhagic Fever with Renal Syndrome (Korean Hemorrhagic Fever).

Descriptive Note : Annual summary rept. 10 Feb 86-9 Feb 87,

Corporate Author : KOREA UNIV SEOUL COLL OF MEDICINE

Personal Author(s) : Lee, Ho W

PDF Url : ADA191301

Report Date : 01 Sep 1987

Pagination or Media Count : 51

Abstract : Hantavirus is ubiquitous in the world but total number of reported HFRS patient in Euro-Asia is about 200,000 with 5-7% mortality annually. Hemorrhagic fever with renal syndrome (HFRS) was an important military problem since large epidemics of HFRS occurred among soldiers in the many past wars and although predominantly associated with field mice in rural areas, it is now being recognized that urban rats and laboratory rates are also reservoirs of HFRS in many parts of the world. Therefore, seroepidemiological survey of distribution of hantaviruses and surveillance of occurrence of HFRS in the world are important for prevention of this highly fatal disease. It is also important to investigate antigenic differences of strains of Hantavirus isolated from rats caught in non-endemic areas of the world because HFRS patient had never been documented in many areas despite our finding of positive rats there. A near global distribution of Hantavirus was demonstrated. HFRS patients infected with Seoul virus occurred in endemic and non-endemic ares of HFRS and the most characteristic clinical features are fever, headache, strong abdominal symptoms, hepatic dysfunction and mild renal dysfunction. Five strains of Seoul virus were isolated from urban rats caught in Hong Kong and Singapore and the strains are a little different antigenically from prototype Seoul virus 80/39 by monoclonal antibody assay. Keywords: ELISA, Bioassay; Laboratory tests; Diagnosis(Medicine).

Descriptors :   *EPIDEMIOLOGY, *HEMORRHAGIC FEVERS, *KIDNEY DISEASES, *VIRUS DISEASES, ABDOMEN, ANTIBODIES, ARMY PERSONNEL, BIOASSAY, CLONES, DISTRIBUTION, DYSFUNCTION, ENZYMES, GLOBAL, HEADACHES, HONG KONG, IMMUNOASSAY, KIDNEYS, KOREA, LABORATORY TESTS, LIVER, MICE, RATS, RURAL AREAS, SIGNS AND SYMPTOMS, SINGAPORE, SURVEILLANCE, URBAN AREAS, MILITARY MEDICINE, DISEASE VECTORS

Subject Categories : Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE