Accession Number : ADA191430

Title :   Mechanisms of Rapid Nonspecific Resistance Induced by Immunomodulators: Delineation Using Selective Depletion of Cells. .

Descriptive Note : Final progress rept.Aug 86-Jul 87,

Corporate Author : MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA DEPT OF MICROBIOLOGY AND IMMUNOLOGY

Personal Author(s) : Morahan, Page S ; Volkman, Alvin

PDF Url : ADA191430

Report Date : 28 Jan 1988

Pagination or Media Count : 47

Abstract : The effects of a wide variety of endogenous and exogenous immunomodulators were applied in mouse models permitting in vivo and in vitro analysis of effector mechanisms in rapid non-specific resistance. Major attention was given to models in which circulating monocytes and NK cells were depleted in short-term and long-term administration of the bone-seeking isotope, strontium. Techniques for the use of free and liposome-encapsulated cytotoxins were studied in vitro and in vivo. Toxins included ricin, ricin A-chain and dichloromethylene diphosphonate (DMDP). Keywords: Macrophages, Monocytes, Listeria, Immunotherapy, Interferons, Immunomodulators, Bone marrow depletion, Liposomes, Prostaglandins, Ricin, Ricin A-chain, Dichloromethylene diphosphonate.

Descriptors :   *BONE MARROW, *IMMUNOCHEMISTRY, *LABELED SUBSTANCES, CIRCULATION, CYTOPLASM, DEPLETION, IN VITRO ANALYSIS, IN VIVO ANALYSIS, INTERFERON, LISTERIA, LONG RANGE(TIME), MICE, MODELS, MONOCYTES, PHOSPHONATES, PROSTAGLANDIN, RESISTANCE, RICIN, STRONTIUM, TOXINS AND ANTITOXINS, RESISTANCE(BIOLOGY), TOXIC TOLERANCES

Subject Categories : Medicine and Medical Research
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE