Accession Number : ADA191439

Title :   Combination Chemotheraphy Using Immune Modulators and Antiviral Drugs against Togaviruses and Bunyaviruses.

Descriptive Note : Annual rept. 1 Mar 86-28 Feb 87,

Corporate Author : TEXAS UNIV MEDICAL BRANCH AT GALVESTON DEPT OF MICROBIOLOGY

Personal Author(s) : Coppenhaver, D H ; Sarzotti, M ; Singh, I P ; Lucia, H ; Baron, S

PDF Url : ADA191439

Report Date : 30 Mar 1987

Pagination or Media Count : 37

Abstract : Infections caused by exotic viruses are an important public health problem world-wide, and are a threat to become more widely desiminated. Representative viruses from four medically important groups were chosen as model systems to investigate potential antiviral therapies. Select Alphaviruses, Flaviviruses, Bunyaviruses, and an Arenavirus (Pichinde) were studied. Model systems were established in vitro and in vivo. In vitro screens of candidate antiviral substances identified compounds of potential therapeutic interest. The most promising compounds were examined in vivo, using Semliki Forest and Banzi weanling mouse models, to establish minimal therapeutic levels. These experiments will form the basis for designing combination therapies using immune modulators and antiviral drugs. Keywords: Immunonodulators, Antivirals, Arboviruses, Arenaviruses, Combination Therapy.

Descriptors :   *ANTIVIRAL AGENTS, *VIRUS DISEASES, DRUGS, ARBOVIRUSES, THERAPY, IMMUNITY, MODULATORS, IN VIVO ANALYSIS, MODELS, PUBLIC HEALTH, GROUP B ARBOVIRUSES, IN VITRO ANALYSIS, SEMLIKI VIRUS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE