Accession Number : ADA192245

Title :   Interactions of Lipid Vesicles with Blood Proteins and Platelets.

Descriptive Note : Final rept. 1 Jan 86-31 Mar 87,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s) : Juliano, Rudolph L

PDF Url : ADA192245

Report Date : 31 Mar 1987

Pagination or Media Count : 31

Abstract : We have examined the interactions of hemoglobin containing liposomes and of liposomes composed of polymerizable phospholipids with blood cells and proteins. All types of liposomes studied bound a variety of serum proteins with IgG being the most abundant component in each case. Polymerized methacrylate liposomes specifically bound a 53 kilodalton protein not bound by other liposome types. None of the liposomes tested provoked platelet aggregation; however, unpolymerized methacrylate liposomes markedly inhibited ADP induced platelet aggregation. Most liposomes tested did not affect clotting of plasma; however, polymerized methacrylate liposomes bound clotting factor V and thus inhibited clotting.

Descriptors :   *BLOOD PLATELETS, *BLOOD PROTEINS, *LIPIDS, BLOOD CELLS, CAVITIES, CYTOPLASM, HEMOGLOBIN, INTERACTIONS, METHACRYLATES, PHOSPHOLIPIDS, POLYMERIZATION, SERUM PROTEINS, BLOOD COAGULATION

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE