Accession Number : ADA192245
Title : Interactions of Lipid Vesicles with Blood Proteins and Platelets.
Descriptive Note : Final rept. 1 Jan 86-31 Mar 87,
Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
Personal Author(s) : Juliano, Rudolph L
PDF Url : ADA192245
Report Date : 31 Mar 1987
Pagination or Media Count : 31
Abstract : We have examined the interactions of hemoglobin containing liposomes and of liposomes composed of polymerizable phospholipids with blood cells and proteins. All types of liposomes studied bound a variety of serum proteins with IgG being the most abundant component in each case. Polymerized methacrylate liposomes specifically bound a 53 kilodalton protein not bound by other liposome types. None of the liposomes tested provoked platelet aggregation; however, unpolymerized methacrylate liposomes markedly inhibited ADP induced platelet aggregation. Most liposomes tested did not affect clotting of plasma; however, polymerized methacrylate liposomes bound clotting factor V and thus inhibited clotting.
Descriptors : *BLOOD PLATELETS, *BLOOD PROTEINS, *LIPIDS, BLOOD CELLS, CAVITIES, CYTOPLASM, HEMOGLOBIN, INTERACTIONS, METHACRYLATES, PHOSPHOLIPIDS, POLYMERIZATION, SERUM PROTEINS, BLOOD COAGULATION
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE