Accession Number : ADA192251

Title :   Fourteen-Day Subchronic Oral Toxicity Study of 4-Nitrophenyl Monochloromethyl (Phenyl) Phosphinate in Male Rats.

Descriptive Note : Final rept. 17 Nov-16 Dec 82,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Lewis, Carlyn M ; White, Craig W ; Kellner, Thomas P ; Waring, Paul P ; Turnier, John C

PDF Url : ADA192251

Report Date : Feb 1988

Pagination or Media Count : 94

Abstract : The 14-day subchronic oral toxicity of 4-nitrophenyl monochloromethyl (phenyl) phosphinate (MCP) was evaluated in male rats. MCP was administered by gavage at dose levels of 0,12.5, 25, 50 and 100 mg/kg/day for 14 days. At necropsy blood samples were obtained for hematological and serum clinical analyses. A complete histological examination was performed on all animals. In addition, plasma, red blood cell, and brain acetylcholinesterase and butyrylcholinesterase activities were determined. Although MCP was lethal to one rat in both the 50 and 100 mg/kg dose groups, no definitive pattern of clinical chemical, hematological or histopathological alterations was found. This suggests that the deaths observed could be due to a transient toxic response associated with cholinesterase inhibition.

Descriptors :   *LETHALITY, *RATS, *PHOSPHINATES, ACETYLCHOLINESTERASE, ANIMALS, AUTOPSY, BLOOD, BLOOD SERUM, BRAIN, CHOLINESTERASE, HEMATOLOGY, HISTOLOGICAL TECHNIQUES, INHIBITION, MALES, RESPONSE, SAMPLING, TOXICITY, TRANSIENTS, PHENYL RADICALS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE